Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CACNA2D1 | P54289 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255445 | 0.78 | CACNA2D1 (0.36) | MEN1KMT2ACACNA2D1CYP2D6SLC6A2 | |
| SCHEMBL11101168 | 0.78 | SIGMAR1 (0.36) | MEN1KMT2ACACNA2D1SLC6A2SLC6A4 | |
| SCHEMBL27360615 | 0.74 | SLC6A4 (0.32) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21634099 | 0.74 | SLC6A4 (0.32) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6616867 | 0.73 | GNAO1 (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL1134921 | 0.73 | SLC6A2 (0.34) | MEN1KMT2ACYP2D6SLC6A2SLC6A4 | |
| SCHEMBL21039175 | 0.71 | SLC6A2 (0.36) | MEN1KMT2ACACNA2D1CYP2D6SLC6A2 | |
| SCHEMBL4557394 | 0.70 | MEN1 (0.39) | MEN1KMT2ACACNA2D1SLC6A4 | |
| SCHEMBL13505803 | 0.69 | SMN1; SMN2 (0.37) | MEN1KMT2ACACNA2D1CYP2D6SLC6A2 | |
| SCHEMBL8666122 | 0.69 | SLC6A2 (0.35) | MEN1KMT2ACACNA2D1CYP2D6SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699798-A4 | DI-SUBSTITUTED PYRROLOTRIAZINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2009-03-11 | — | — | EP | disclosed |
| EP-1699798-A2 | DI-SUBSTITUTED PYRROLOTRIAZINE COMPOUNDS | Bristol-Myers Squibb Company (US) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005065266-A2 | DI-SUBSTITUTED PYRROLOTRIAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-07-21 | — | — | WO | disclosed |