SCHEMBL4544847

SCHEMBL4544847

CCOC(=O)c1ccc(Nc2nc(Nc3ccc(C(=O)OCC)cc3)nc(Nc3ccccc3CC)n2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 6/20 0.64
KMT2A Q03164 6/20 0.64
RAB9A P51151 4/20 0.64
THRB P10828 1/20 0.64
PDPK1 O15530 1/20 0.59
HTT P42858 1/20 0.57
SLC2A1 P11166 1/20 0.54
SMN1; SMN2 Q16637 6/20 0.54
NPC1 O15118 4/20 0.54
ALDH1A1 P00352 2/20 0.54
CASP3 P42574 1/20 0.54
SENP7 Q9BQF6 1/20 0.54
AURKA O14965 1/20 0.53
MAPT P10636 5/20 0.52
POLB P06746 2/20 0.52
KDM4E B2RXH2 2/20 0.52
GAA P10253 2/20 0.52
HPGD P15428 2/20 0.52
RXFP1 Q9HBX9 1/20 0.52
EGFR P00533 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13799946 0.96 MEN1 (0.60) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL10033678 0.90 HTT (0.54) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL19088133 0.88 MEN1 (0.64) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL12253193 0.87 MEN1 (0.83) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL4544848 0.83 KMT2A (0.76) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL4544842 0.81 KCNH3 (0.50) MEN1KMT2ARAB9ASMN1; SMN2NPC1
SCHEMBL13852878 0.80 MEN1 (0.72) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL4544859 0.79 KCNH3 (0.51) MEN1KMT2AALDH1A1MAPTKDM4E
SCHEMBL4544865 0.79 MEN1 (0.67) MEN1KMT2ARAB9ATHRBPDPK1
SCHEMBL11307824 0.79 MEN1 (0.63) MEN1KMT2ARAB9ATHRBPDPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9223070-B2 Optical film, polarizing plate equipped with the optical film, process for manufacture of the polarizing plate, and liquid crystal display device Konica Minolta, Inc. (JP) 2015-12-29 US disclosed
US-20150253480-A1 RETARDATION FILM, ELONGATED CIRCULARLY POLARIZING PLATE AND ORGANIC EL DISPLAY PRODUCED USING SAID RETARDATION FILM Konica Minolta, Inc. (JP) 2015-09-10 US disclosed
US-9110243-B2 Laminate film, optically compensatory film, polarizing plate, and liquid crystal display device FUJIFILM CORPORATION (JP) 2015-08-18 US disclosed
US-9103988-B2 Liquid-crystal display device FUJIFILM CORPORATION (JP) 2015-08-11 US disclosed
US-8976325-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2015-03-10 US disclosed
US-20150033984-A1 CELLULOSE ACYLATE FILM, POLARIZING PLATE, MANUFACTURING METHOD OF POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2015-02-05 US disclosed
US-8947621-B2 Liquid crystal display device comprising a front plate having a lamda/4 plate that includes a hard coat layer and method for manufacturing the same KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2015-02-03 US disclosed
US-8681295-B2 VA-mode liquid-crystal display device FUJIFILM CORPORATION (JP) 2014-03-25 US disclosed
US-20130293812-A1 OPTICAL FILM, POLARIZING PLATE EQUIPPED WITH THE OPTICAL FILM, PROCESS FOR MANUFACTURE OF THE POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE Konica Minolta, Inc. (JP) 2013-11-07 US disclosed
US-20130169897-A1 METHOD FOR MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE WITH FRONT PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE WITH FRONT PLATE KONICA MINOLTA ADVANCED LAYERS, INC. (JP) 2013-07-04 US disclosed
US-7651743-B2 Cellulose acylate film, manufacturing method of cellulose acylate film, optically compensatory sheet, polarizing plate and liquid crystal display device FUJIFILM CORPORATION (JP) 2010-01-26 US disclosed
US-7611760-B2 Cellulose acylate film, optical compensation film, polarizing plate and liquid crystal display FUJIFILM CORPORATION (JP) 2009-11-03 US disclosed
US-20090251650-A1 Liquid crystal display device FUJIFILM CORPORATION (JP) 2009-10-08 US disclosed
US-20090080074-A1 POLYMER FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE FUJIFILM CORPORATION (JP) 2009-03-26 US disclosed
US-20090066887-A1 Polymer Film, Polarizing Plate Protective Film, Polarizing Plate and Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2009-03-12 US disclosed
US-20080204644-A1 Liquid crystal display device FUJIFILM CORPORATION (JP) 2008-08-28 US disclosed
US-20080198303-A1 Polarizing plate and liquid crystal display device FUJIFILM CORPORATION (JP) 2008-08-21 US disclosed
US-20080143928-A1 Polarizing Plate and Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-19 US disclosed
US-20080137014-A1 Liquid Crystal Display Device FUJIFILM CORPORATION (JP) 2008-06-12 US disclosed
US-20080013173-A1 METHOD OF MANUFACTURING A POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE KONICA MINOLTA OPTO, INC. (JP) 2008-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090080074-A1 POLYMER FILM, POLARIZING PLATE PROTECTIVE FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE RPA3, RTF1, RPA1 MEN1 2012/4885KMT2A 3282/4885RAB9A 886/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.