Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 19/20 | 0.90 |
| ▸ | DRD2 | P14416 | 1/20 | 0.63 |
| ▸ | DRD4 | P21917 | 1/20 | 0.63 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13533303 | 0.96 | HTR1A (0.87) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL30628143 | 0.95 | HTR1A (1.00) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL5184178 | 0.95 | HTR1A (1.00) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL4546540 | 0.95 | HTR1A (1.00) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL4546541 | 0.91 | HTR1A (0.78) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL13533293 | 0.88 | HTR1A (0.73) | HTR1A | |
| SCHEMBL13533295 | 0.85 | HTR1A (0.73) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL14164158 | 0.84 | HTR1A (0.89) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL13959413 | 0.84 | HTR1A (0.81) | HTR1ADRD2DRD4DRD3 | |
| SCHEMBL5184137 | 0.83 | HTR1A (1.00) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168786-B2 | 1,2,4-triazole- 3,5-dione derivatives; for imaging and therapy of psychiatric, eating, sleeping, bipolar disorder; anxiolytic agent, antidepressant; Alzheimer's, Parkinson's diseases, epilepsy; imaging agents for a serotonin receptor | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-05-01 | — | — | US | disclosed |
| US-20080138283-A1 | Radiolabeled compounds and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2008-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080138283-A1 | Radiolabeled compounds and uses thereof | HTR5A, SLC18A2, HTR1A | HTR1A 3/4885DRD2 37/4885DRD4 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.