Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 2/20 | 0.47 |
| ▸ | PFKFB3 | Q16875 | 2/20 | 0.43 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 8/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.40 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.40 |
| ▸ | PFKFB4 | Q16877 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1850691 | 0.89 | IMPDH2 (0.57) | IMPDH2PFKFB3AURKAAURKBPDE4A | |
| SCHEMBL1849634 | 0.88 | CYP19A1 (0.52) | IMPDH2PFKFB3ENPP1PDE4APDE4B | |
| SCHEMBL1848921 | 0.88 | ENPP1 (0.54) | IMPDH2PFKFB3ENPP1AURKAAURKB | |
| SCHEMBL13534569 | 0.88 | HTR6 (0.50) | IMPDH2PFKFB3ENPP1AURKAAURKB | |
| SCHEMBL1847855 | 0.88 | F2 (0.52) | IMPDH2PFKFB3AURKAAURKBMAP2K7 | |
| SCHEMBL1847710 | 0.86 | CYP19A1 (0.56) | IMPDH2PFKFB3ENPP1AURKAAURKB | |
| SCHEMBL1852646 | 0.86 | ERAP1 (0.53) | IMPDH2PFKFB3NTRK1MAP2K4MEN1 | |
| SCHEMBL1848169 | 0.85 | SLC22A12 (0.47) | IMPDH2PFKFB3ENPP1MAP2K4 | |
| SCHEMBL1849086 | 0.85 | AURKA (0.51) | IMPDH2PFKFB3AURKAAURKBMEN1 | |
| SCHEMBL1849348 | 0.84 | CA12 (0.51) | IMPDH2PFKFB3AURKAAURKBMAP2K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2324008-B1 | 3,4-DIARYLPYRAZOLES AS PROTEIN KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2012-05-09 | — | — | EP | disclosed |