Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL454757 | 1.00 | MEN1 (0.48) | MEN1KMT2ATDP1MAPK1NPSR1 | |
| SCHEMBL4487191 | 0.78 | TDP1 (0.51) | MEN1KMT2ATDP1MAPK1NPSR1 | |
| SCHEMBL4487187 | 0.78 | TDP1 (0.51) | MEN1KMT2ATDP1MAPK1NPSR1 | |
| SCHEMBL4487195 | 0.78 | TDP1 (0.51) | MEN1KMT2ATDP1MAPK1NPSR1 | |
| SCHEMBL444521 | 0.77 | MAPK1 (0.42) | KMT2ATDP1MAPK1IDO1ALDH1A1 | |
| SCHEMBL454398 | 0.77 | MAPK1 (0.42) | KMT2ATDP1MAPK1IDO1ALDH1A1 | |
| SCHEMBL454399 | 0.77 | MAPK1 (0.42) | KMT2ATDP1MAPK1IDO1ALDH1A1 | |
| SCHEMBL1829314 | 0.76 | LOXL2 (0.57) | MEN1KMT2ATDP1LOXL2IDO1 | |
| SCHEMBL30401215 | 0.71 | CYP1A2 (0.51) | MEN1KMT2AMAPK1ALDH1A1MAPT | |
| SCHEMBL29880371 | 0.71 | CYP1A2 (0.51) | MEN1KMT2AMAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470739-B2 | Isothiazolyloxyphenylamidines and their use as fungicides | BAYER CROPSCIENE AG (DE) | 2013-06-25 | — | — | US | disclosed |
| US-8138211-B2 | Isothiazolyloxyphenylamidines and their use as fungicides | BAYER CROPSCIENCE AG (DE) | 2012-03-20 | — | — | US | disclosed |
| US-20120065061-A1 | ISOTHIAZOLYLOXYPHENYLAMIDINES AND THEIR USE AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2012-03-15 | — | — | US | disclosed |
| EP-2391612-A1 | Isothiazolyloxyphenyl amidines and use thereof as fungicides | Bayer CropScience AG (DE) | 2011-12-07 | — | — | EP | disclosed |
| US-20110130282-A1 | Isothiazolyloxyphenylamidines and their use as fungicides | BAYER CROPSCIENCE AG (DE) | 2011-06-02 | — | — | US | disclosed |
| EP-2223917-A1 | Isothiazolyloxyphenylamidines and their use as fungicides | Bayer CropScience AG (DE) | 2010-09-01 | — | — | EP | disclosed |
| WO-2010086118-A1 | ISOTHIAZOLYLOXYPHENYL AMIDINES AND USE THEREOF AS FUNGICIDES | BAYER CROPSCIENCE AG (DE) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065061-A1 | ISOTHIAZOLYLOXYPHENYLAMIDINES AND THEIR USE AS FUNGICIDES | DDT, CYP3A5, INMT | MEN1 784/4885KMT2A 2601/4885TDP1 731/4885 |
| US-20110130282-A1 | Isothiazolyloxyphenylamidines and their use as fungicides | DDT, CYP3A5, INMT | MEN1 784/4885KMT2A 2601/4885TDP1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.