Sugi Predict

Sugi Predict / Compounds / SCHEMBL4548071

SCHEMBL4548071

SCHEMBL4548071

O=C(Nc1ccccc1)Nc1ccc(C(F)(F)F)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ EPHX2 P34913 4/20 0.85
▸ RAB9A P51151 4/20 0.72
▸ MAPT P10636 3/20 0.72
▸ MEN1 O00255 2/20 0.72
▸ HTT P42858 2/20 0.72
▸ KMT2A Q03164 2/20 0.72
▸ NPC1 O15118 2/20 0.71
▸ BAZ1A Q9NRL2 1/20 0.71
▸ MTOR P42345 1/20 0.71
▸ TP53 P04637 1/20 0.65
▸ EPHX1 P07099 1/20 0.65
▸ TSHR P16473 1/20 0.65
▸ CDK9 P50750 1/20 0.65
▸ SMN1; SMN2 Q16637 1/20 0.65
▸ CLK4 Q9HAZ1 1/20 0.65
▸ CA12 O43570 1/20 0.63
▸ CA1 P00915 1/20 0.63
▸ CA2 P00918 1/20 0.63
▸ CA9 Q16790 1/20 0.63
▸ CASP3 P42574 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28729179 0.92 EPHX2 (1.00) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL11003408 0.92 EPHX2 (1.00) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL12010918 0.92 RAB9A (0.81) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL19501818 0.92 RAB9A (0.81) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL4265086 0.87 EPHX2 (0.69) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL3346579 0.85 MAPT (0.68) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL671986 0.85 MAPT (0.78) EPHX2RAB9AMAPTMEN1HTT
SCHEMBL7877746 0.85 EPHX2 (0.90) EPHX2RAB9AMAPTNPC1BAZ1A
SCHEMBL12010881 0.85 MEN1 (0.68) EPHX2MAPTMEN1HTTKMT2A
SCHEMBL18031166 0.85 EPHX2 (0.85) EPHX2RAB9AMAPTMEN1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117924679-A Thiol-containing biodegradable polyester polymer material and synthesis method thereof 浙大城市学院 2024-04-26 — — CN claimed
CN-117887051-A High-density oxygen-containing heterocycle functionalized polylactic acid molecule and synthesis method thereof 浙大城市学院 2024-04-16 — — CN claimed
WO-2006130426-A2 MODULATORS OF CCR-5 ACTIVITY KEMIA, INC. (US) 2006-12-07 — — WO claimed
CN-117924679-A Thiol-containing biodegradable polyester polymer material and synthesis method thereof 浙大城市学院 2024-04-26 — — CN disclosed
CN-117887051-A High-density oxygen-containing heterocycle functionalized polylactic acid molecule and synthesis method thereof 浙大城市学院 2024-04-16 — — CN disclosed
CN-109627429-B Preparation method of high molecular weight poly (gamma-butyrolactone) 青岛博远高分子材料研究院有限公司 2024-04-16 — — CN disclosed
CN-114369232-B Renewable degradable thermoplastic elastomer and preparation method thereof 青岛科技大学 2023-10-20 — — CN disclosed
CN-114369232-A Renewable degradable thermoplastic elastomer and preparation method thereof 青岛科技大学 2022-04-19 — — CN disclosed
WO-2020083180-A1 METHOD FOR PREPARING POLY(γ-BUTYROLACTONE) WITH HIGH MOLECULAR WEIGHT 青岛科技大学 2020-04-30 — — WO disclosed
WO-2019149086-A1 POLYETHER-B-POLY (γ-BUTYROLACTONE) BLOCK COPOLYMER AND PREPARATION METHOD THEREFOR 青岛科技大学 2019-08-08 — — WO disclosed
US-9932300-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2018-04-03 — — US disclosed
US-9421211-B2 N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2016-08-23 — — US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2012-05-10 — — US disclosed
US-7868064-B2 Ink receptive particles, material for recording, recording apparatus and ink receptive particle storage cartridge FUJI XEROX CO., LTD. (JP) 2011-01-11 — — US disclosed
US-7851518-B2 Ink receptive particles, material for recording, recording apparatus and ink receptive particle storage cartridge FUJI XEROX CO., LTD. (JP) 2010-12-14 — — US disclosed
US-20100045761-A1 INK RECEPTIVE PARTICLES, MATERIAL FOR RECORDING, RECORDING APPARATUS AND INK RECEPTIVE PARTICLE STORAGE CARTRIDGE FUJI XEROX CO., LTD. (JP) 2010-02-25 — — US disclosed
US-20100041812-A1 INK RECEPTIVE PARTICLES, MATERIAL FOR RECORDING, RECORDING APPARATUS AND INK RECEPTIVE PARTICLE STORAGE CARTRIDGE FUJI XEROX CO., LTD. (JP) 2010-02-18 — — US disclosed
US-7638562-B2 Ink receptive particles, material for recording, recording apparatus and ink receptive particle storage cartridge FUJI XEROX CO., LTD. (JP) 2009-12-29 — — US disclosed
US-20080032074-A1 Ink receptive particles, material for recording, recording apparatus and ink receptive particle storage cartridge FUJI XEROX CO., LTD. 2008-02-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120115915-A1 N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION NSUN2, EIF2AK2, RNGTT EPHX2 3547/4885RAB9A 2490/4885MAPT 1631/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.