Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 3/20 | 0.66 |
| ▸ | MET | P08581 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 14/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.61 |
| ▸ | LCK | P06239 | 2/20 | 0.61 |
| ▸ | TEK | Q02763 | 2/20 | 0.61 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.61 |
| ▸ | CSF1R | P07333 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | FLT1 | P17948 | 1/20 | 0.61 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.61 |
| ▸ | FLT4 | P35916 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | AXL | P30530 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2748446 | 0.98 | PDGFRA (0.68) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL2748028 | 0.93 | PDGFRA (0.69) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL4548874 | 0.92 | KDR (0.60) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL4548872 | 0.91 | KDR (0.70) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL4548863 | 0.91 | KDR (0.70) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL2747795 | 0.90 | MET (0.75) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL4548864 | 0.90 | MET (0.60) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL2749286 | 0.89 | KDR (0.64) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL2749260 | 0.89 | MET (0.64) | PDGFRAMETKDRAURKALCK | |
| SCHEMBL4548852 | 0.89 | KDR (0.71) | PDGFRAMETKDRAURKALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | PDGFRA 49/4885MET 3/4885KDR 354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.