Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 13/20 | 0.68 |
| ▸ | KIT | P10721 | 4/20 | 0.68 |
| ▸ | MET | P08581 | 5/20 | 0.62 |
| ▸ | KDR | P35968 | 11/20 | 0.59 |
| ▸ | AURKA | O14965 | 3/20 | 0.57 |
| ▸ | LCK | P06239 | 3/20 | 0.57 |
| ▸ | TEK | Q02763 | 3/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.54 |
| ▸ | LYN | P07948 | 1/20 | 0.54 |
| ▸ | FGR | P09769 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2746340 | 0.98 | PDGFRA (0.70) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL2749849 | 0.97 | PDGFRA (0.71) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL2747714 | 0.96 | PDGFRA (0.67) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL4548869 | 0.96 | MET (0.64) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL7476534 | 0.90 | PDGFRA (0.81) | PDGFRAKITKDRAURKBFLT3 | |
| SCHEMBL7480525 | 0.89 | PDGFRA (0.82) | PDGFRAKITKDRAURKBFLT3 | |
| SCHEMBL4548859 | 0.83 | MET (0.65) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL4549019 | 0.83 | KDR (0.66) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL2747856 | 0.83 | MET (0.67) | PDGFRAKITMETKDRAURKA | |
| SCHEMBL5825514 | 0.81 | PDGFRA (0.98) | PDGFRAKITMETKDRAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | PDGFRA 49/4885KIT 682/4885MET 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.