Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.75 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 4/20 | 0.52 |
| ▸ | RET | P07949 | 3/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.48 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4548912 | 0.90 | KDR (0.84) | KDRFLT1BRAFMAPK14TNNI3K | |
| SCHEMBL4548920 | 0.86 | KDR (0.85) | KDRFLT1BRAFMAPK14TNNI3K | |
| SCHEMBL4548917 | 0.86 | KDR (0.75) | KDRFLT1FLT3BRAFMAPK14 | |
| SCHEMBL4548941 | 0.85 | KDR (0.77) | KDRFLT1RETPDGFRBBRAF | |
| SCHEMBL4548913 | 0.85 | KDR (0.83) | KDRFLT1BRAFMAPK14TNNI3K | |
| SCHEMBL4548939 | 0.85 | KDR (0.77) | KDRFLT1BRAFMAPK14TNNI3K | |
| SCHEMBL4548914 | 0.85 | KDR (0.83) | KDRCYP3A4CYP2D6FLT1BRAF | |
| SCHEMBL4812261 | 0.85 | KDR (1.00) | KDRFLT1BRAFMAPK14TNNI3K | |
| SCHEMBL4548926 | 0.85 | KDR (0.73) | KDRFLT1RETPDGFRBBRAF | |
| SCHEMBL4548938 | 0.85 | KDR (0.76) | KDRCYP3A4CYP2D6FLT1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-8178557-B2 | Compounds and methods of use | AMGEN INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-20090176774-A1 | Compounds and methods of use | AMGEN INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
| US-7435823-B2 | Compounds and methods of use | AMGEN INC. (US) | 2008-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176774-A1 | Compounds and methods of use | HGF, HGFAC, MET | KDR 354/4885CYP3A4 348/4885CYP2D6 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.