Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.94 |
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.42 |
| ▸ | CPT2 | P23786 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL460208 | 1.00 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL17760706 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20590930 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1684053 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20954938 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9319654 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21802305 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL20994443 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL22558234 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10477645 | 0.97 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 275 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110327301-A | The good dextrorotation Oxiracetam freeze drying powder injection and preparation method thereof of stability | 重庆润泽医药有限公司 | 2019-10-15 | — | — | CN | claimed |
| CN-110314143-A | Injection dextrorotation Oxiracetam lyophilized preparation and preparation method thereof | 重庆润泽医药有限公司 | 2019-10-11 | — | — | CN | claimed |
| CN-110314142-A | A kind of no crystal water dextrorotation oxiracetam freeze drying powder injection and preparation method thereof | 重庆润泽医药有限公司 | 2019-10-11 | — | — | CN | claimed |
| CN-110314139-A | The good dextrorotation oxiracetam lyophilized preparation and preparation method thereof of solubility | 重庆润泽医药有限公司 | 2019-10-11 | — | — | CN | claimed |
| CN-110314138-A | Freeze-dried composition and preparation method thereof comprising dextrorotation oxiracetam | 重庆润泽医药有限公司 | 2019-10-11 | — | — | CN | claimed |
| CN-110063915-A | A kind of toothpaste core material and its soft core solid tooth-paste of manufactured crackling | 广州纳英化工有限公司 | 2019-07-30 | — | — | CN | claimed |
| CN-110051686-A | Composition comprising cross-linked cationic conjugated polymer | 瑞立普萨公司 | 2019-07-26 | — | — | CN | claimed |
| CN-109996533-A | Stabilization formulations for parenteral administration tapentadol hydrochloride | 格吕伦塔尔有限公司 | 2019-07-09 | — | — | CN | claimed |
| CN-107847471-A | The stabilization formulations of tapentadol hydrochloride parenteral | 格吕伦塔尔有限公司 | 2018-03-27 | — | — | CN | claimed |
| CN-107531958-A | Process for foaming polyolefin compositions using azodicarbonamide/citrate mixtures as nucleating agents | 陶氏环球技术有限责任公司 | 2018-01-02 | — | — | CN | claimed |
| CN-101491548-A | Suspension suitable for animal directly-drinking and preparation method thereof | TIANJIN RUIPU BIOTECHNOLOGY CO (CN) | 2009-07-29 | — | — | CN | claimed |
| CN-101475579-A | Stable cefuroxime sodium and preparation thereof | GUANGZHOU BAIYUNSHAN PHARMACEU (CN) | 2009-07-08 | — | — | CN | claimed |
| CN-101450038-A | Nicarbazin and ethopabate nano suspension agent and preparation method thereof | TIANJIN RUIPU BIOTECHNOLOGY CO (CN) | 2009-06-10 | — | — | CN | claimed |
| CN-101367573-A | Compound for wastewater treatment | XIANGBO JIA (CN) | 2009-02-18 | — | — | CN | claimed |
| WO-2009010531-A1 | NOVEL ONE STEP PROCESS FOR PREPARING CROSS-LINKED POLY(ALLYLAMINE) POLYMERS | CHEMO IBÉRICA, S.A. (ES) | 2009-01-22 | — | — | WO | claimed |
| EP-2016947-A1 | Novel one step process for preparing cross-linked poly(allylamine) polymers | Chemo Ibérica, S.A. (ES) | 2009-01-21 | — | — | EP | claimed |
| CN-1271096-C | Alkylation of cross-linked polymers contg. N-or amino-or mamonium groups | DSM FINE CHEM AUSTRIA GMBH (AT) | 2006-08-23 | — | — | CN | claimed |
| CN-1600301-A | External remedy for treating psoriasis | LI YUEHENG (CN) | 2005-03-30 | — | — | CN | claimed |
| CN-1600300-A | Compound external remedy for treating psoriasis | LI YUEHENG (CN) | 2005-03-30 | — | — | CN | claimed |
| CN-1481396-A | Alkylation of cross-linked polymers contg. N-or amino-or mamonium groups | DSM��ϸ��ѧ�µ���NFG���Ϲ�˾ | 2004-03-10 | — | — | CN | claimed |