Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.46 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CPT2 | P23786 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL460208 | 0.97 | ALDH1A1 (0.94) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL664207 | 0.97 | ALDH1A1 (0.94) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL9299044 | 0.97 | ALDH1A1 (0.94) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL227914 | 0.97 | ALDH1A1 (0.94) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL29629071 | 0.97 | ALDH1A1 (0.94) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL45491 | 0.97 | ALDH1A1 (0.94) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL5425793 | 0.94 | ALDH1A1 (0.88) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL20590930 | 0.94 | ALDH1A1 (0.88) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL21802305 | 0.94 | ALDH1A1 (0.88) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R | |
| Citric Acid SCHEMBL22558234 | 0.94 | ALDH1A1 (0.88) | ALDH1A1SLC13A5HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4180414-B1 | METHOD FOR MANUFACTURING MONO CALCIUM CITRATE BY USING SHELL AND APPLICATION THEREOF | KOREA RES INST CHEMICAL TECH (KR) | 2025-11-26 | — | — | EP | claimed |
| CN-114711432-A | Water-soluble calcium and preparation method thereof, calcium agent and application of water-soluble calcium | 云南莱德福科技有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-111847930-B | Carbon nano tube/calcium aluminate cement, preparation method and application | 西安建筑科技大学 | 2022-05-27 | — | — | CN | claimed |
| CN-111847930-A | Carbon nano tube/calcium aluminate cement, preparation method and application | 西安建筑科技大学 | 2020-10-30 | — | — | CN | claimed |
| JP-9040604-A | — | — | None | — | — | JP | disclosed |
| EP-4180414-B1 | METHOD FOR MANUFACTURING MONO CALCIUM CITRATE BY USING SHELL AND APPLICATION THEREOF | KOREA RES INST CHEMICAL TECH (KR) | 2025-11-26 | — | — | EP | disclosed |
| CN-120098647-A | Soda saline-alkali soil targeted alkaline agent and preparation and use methods thereof | 吉林协联农业科技有限公司 | 2025-06-06 | — | — | CN | disclosed |
| CN-116283581-A | Method for preparing glycerol carbonate by catalyzing glycerol and carbonate through bio-based carboxylate catalyst | 四川大学 | 2023-06-23 | — | — | CN | disclosed |
| CN-114711432-A | Water-soluble calcium and preparation method thereof, calcium agent and application of water-soluble calcium | 云南莱德福科技有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114711432-A | Water-soluble calcium and preparation method thereof, calcium agent and application of water-soluble calcium | 云南莱德福科技有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-111847930-B | Carbon nano tube/calcium aluminate cement, preparation method and application | 西安建筑科技大学 | 2022-05-27 | — | — | CN | disclosed |
| CN-112409167-A | Preparation method of calcium citrate whisker | 日照金禾博源生化有限公司 | 2021-02-26 | — | — | CN | disclosed |
| WO-2011047634-A1 | METHOD FOR PREPARING CITRIC ACID | COFCO LIMITED (CN) | 2011-04-28 | — | — | WO | disclosed |
| CN-101648864-A | Purification method of citric acid fermentation broth | ANHUI BBCA BIOCHEMICAL CO LTD | 2010-02-17 | — | — | CN | disclosed |
| CN-101117315-A | Production method of lemon acid | ANHUI FENGYUAN BIOLOG CHEMICAL (CN) | 2008-02-06 | — | — | CN | disclosed |
| CN-101117314-A | Production method of sodium citrate | ANHUI FENGYUAN BIOLOG CHEMICAL (CN) | 2008-02-06 | — | — | CN | disclosed |
| WO-2007035760-A1 | ENHANCED SOLUBILITY OF PREFORMED CALCIUM CITRATE BY ADDING CITRIC ACID | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-03-29 | — | — | WO | disclosed |
| US-20070065542-A1 | Enhanced solubility of preformed calcium citrate by adding citric acid | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-03-22 | — | — | US | disclosed |
| JP-H0940604-A | PURIFICATION OF CITRIC ACID | NIPPON SHOKUBAI CO LTD | 1997-02-10 | — | — | JP | disclosed |
| US-4324775-A | SCRUBBING WITH ALKALI METAL SALT OF DIVALENT ANION, ION EXCHANGING WITH AMINE SALT | TUNG SHAO E | 1982-04-13 | — | — | US | disclosed |