Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | PRF1 | P14222 | 6/20 | 0.50 |
| ▸ | MAOA | P21397 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18472558 | 0.81 | MAPT (0.54) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL18472563 | 0.81 | MAPT (0.54) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL286642 | 0.81 | MAPT (0.54) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL31736923 | 0.80 | DRD2 (0.53) | MAOAMAOBKCNJ1KCNH2 | |
| SCHEMBL6103471 | 0.79 | MAPT (0.53) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL22103559 | 0.79 | MAPT (0.53) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL16107309 | 0.74 | MAPT (0.47) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL20574951 | 0.72 | MAPT (0.45) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL855289 | 0.72 | MAPT (0.61) | MAPTLMNAGAAPRF1MAOA | |
| SCHEMBL365201 | 0.72 | MAPT (0.61) | MAPTLMNAGAAPRF1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012058134-A1 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2012-05-03 | — | — | WO | disclosed |