SCHEMBL4550663

SCHEMBL4550663

ClOCc1c(Cl)cc(Cl)cc1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
TSHR P16473 5/20 0.38
HSD17B10 Q99714 3/20 0.38
CYP3A4 P08684 2/20 0.38
RECQL P46063 2/20 0.38
IDO1 P14902 5/20 0.36
HPGD P15428 2/20 0.33
AHR P35869 1/20 0.33
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
TP53 P04637 1/20 0.32
KDM4E B2RXH2 1/20 0.30
MEN1 O00255 1/20 0.30
SLC22A2 O15244 1/20 0.30
SLC22A1 O15245 1/20 0.30
NR1I2 O75469 1/20 0.30
SLC22A3 O75751 1/20 0.30
EGFR P00533 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2095743 0.77 ALDH1A1 (0.39) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL2095745 0.77 ALDH1A1 (0.39) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL8258388 0.72 BDKRB2 (0.39) ALDH1A1KDM4ESMN1; SMN2
SCHEMBL97308 0.72 ALDH1A1 (0.35) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL97309 0.72 ERN1 (0.36) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL29074259 0.71 ALDH1A1 (0.50) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL1589735 0.69 ALDH1A1 (0.47) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL6298851 0.69 CA1 (0.38) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL14972294 0.69 ALDH1A1 (0.36) ALDH1A1TSHRHSD17B10CYP3A4RECQL
SCHEMBL15996542 0.68 TDP1 (0.40) ALDH1A1TSHRKDM4EPOLBCASP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1682506-B1 DIPEPTIDE-ANALOGUE SYNTHESIS BOEHRINGER INGELHEIM PHARMA (US) 2009-12-30 EP claimed
EP-1682506-A1 DIPEPTIDE-ANALOGUE SYNTHESIS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2006-07-26 EP claimed
WO-2005044799-A1 DIPEPTIDE-ANALOGUE SYNTHESIS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2005-05-19 WO claimed
EP-1682506-B1 DIPEPTIDE-ANALOGUE SYNTHESIS BOEHRINGER INGELHEIM PHARMA (US) 2009-12-30 EP disclosed
EP-1682506-A1 DIPEPTIDE-ANALOGUE SYNTHESIS BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) 2006-07-26 EP disclosed
WO-2005044799-A1 DIPEPTIDE-ANALOGUE SYNTHESIS BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) 2005-05-19 WO disclosed