Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 9/20 | 0.39 |
| ▸ | PIK3C2A | O00443 | 2/20 | 0.39 |
| ▸ | PIK3C2B | O00750 | 2/20 | 0.39 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692457 | 0.95 | PIK3CA (0.40) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL4550836 | 0.92 | ACHE (0.35) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL4550891 | 0.89 | KCNH2 (0.33) | PIK3CAPI4KBPIK3CDACHEGRIN2B | |
| SCHEMBL691858 | 0.83 | PI4KB (0.39) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL4547347 | 0.82 | CYP3A4 (0.35) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL12649331 | 0.82 | PI4KB (0.40) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL4547280 | 0.82 | PIK3CG (0.39) | PIK3CAPI4KBPIK3CDAURKACCNA2 | |
| SCHEMBL12651847 | 0.81 | AURKA (0.32) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL4550902 | 0.81 | ALDH1A1 (0.34) | PIK3CAPI4KBPIK3C2APIK3C2BSTK17A | |
| SCHEMBL4547328 | 0.81 | ALDH1A1 (0.36) | PI4KBPIK3C2APIK3C2BSTK17APIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304556-B2 | Thiazolyl-dihydro-indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-11-06 | — | — | US | disclosed |
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-05-03 | — | — | US | disclosed |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-05-19 | — | — | US | disclosed |
| WO-2009112565-A1 | THIAZOLYL-DIHYDRO-INDAZOLES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108567-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | PIK3CA 2993/4885PI4KB 2248/4885PIK3C2A 3890/4885 |
| US-20110118208-A1 | Thiazolyl-Dihydro-Indazoles | MKI67, CYP11B1, IGF1R | PIK3CA 2993/4885PI4KB 2248/4885PIK3C2A 3890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.