Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TP53BP1 | Q12888 | 4/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477727 | 0.94 | KDM4E (0.42) | KDM4EMAPK1HIF1AGAAKDM4C | |
| SCHEMBL8475877 | 0.92 | KDM4E (0.46) | KDM4EMAPK1HIF1APAOXPOLB | |
| SCHEMBL7127257 | 0.88 | GAA (0.35) | KDM4EMAPK1HIF1AGAAKDM4C | |
| SCHEMBL24779728 | 0.87 | EPHX1 (0.41) | KDM4C | |
| SCHEMBL7129242 | 0.85 | — | — | |
| SCHEMBL7129237 | 0.85 | — | — | |
| SCHEMBL8476029 | 0.82 | MEN1 (0.37) | KDM4EMAPK1HIF1APAOXPOLB | |
| SCHEMBL7130257 | 0.82 | — | — | |
| SCHEMBL12248067 | 0.80 | APP (0.37) | KDM4EMAPK1HIF1A | |
| SCHEMBL26452808 | 0.79 | PAOX (0.37) | KDM4EGAAPAOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177326-A1 | SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS | The Ohio State Innovation Foundation (US) | 2017-06-14 | — | — | EP | claimed |
| WO-2016022987-A1 | SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS | OHIO STATE INNOVATION FOUNDATION (US) | 2016-02-11 | — | — | WO | claimed |
| US-20140363378-A1 | SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS | THE OHIO STATE UNIVERSITY | 2014-12-11 | — | — | US | claimed |
| WO-2013116645-A1 | SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS | THE OHIO STATE UNIVERSITY (US) | 2013-08-08 | — | — | WO | claimed |
| US-6660246-B1 | 3,3,9,9-Tetramethyl-4,8-diazaundecane-2,10-dione 2-Hydrazone 10-Oxime; | BRACCO INTERNATIONAL, BV (NL) | 2003-12-09 | — | — | US | claimed |
| US-5776894-A | Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors | NOVARTIS AG (CH) | 1998-07-07 | — | — | US | claimed |
| US-5753627-A | Use of certain complexed somatostatin peptides for the invivo imaging of somatostatin receptor-positive tumors and metastasis | NOVARTIS AG (CH) | 1998-05-19 | — | — | US | claimed |
| EP-0688313-B1 | LIGANDS AND METAL COMPLEXES THEREOF | BRACCO INT BV (NL) | 1998-04-08 | — | — | EP | claimed |
| US-5663307-A | Hydrazone containing ligands and metal complexes thereof | BRACCO INTERNATIONAL B.V. | 1997-09-02 | — | — | US | claimed |
| EP-0688313-A1 | LIGANDS AND METAL COMPLEXES THEREOF | BRACCO International B.V. (NL) | 1995-12-27 | — | — | EP | claimed |
| WO-1995019338-A1 | LIGANDS AND METAL COMPLEXES THEREOF | BRACCO INTERNATIONAL B.V. (NL) | 1995-07-20 | — | — | WO | claimed |
| EP-0123504-B1 | COMPLEXES OF TECHNETIUM-99M WITH ALKYLENE AMINE OXIMES | AMERSHAM INTERNATIONAL plc (GB) | 1989-09-20 | — | — | EP | claimed |
| CN-111225679-B | Novel peptide-based cancer imaging agents | 俄亥俄州创新基金会 | 2024-03-29 | — | — | CN | disclosed |
| US-20230338584-A1 | NOVEL PEPTIDE-BASED CANCER IMAGING AGENTS | OHIO STATE INNOVATION FOUNDATION | 2023-10-26 | — | — | US | disclosed |
| WO-2023086152-A1 | SYSTEMS AND METHODS FOR THE PRODUCTION OF METHEMOGLOBIN AND ITS DERIVATIVES | OHIO STATE INNOVATION FOUNDATION (US) | 2023-05-19 | — | — | WO | disclosed |
| US-20220218834-A1 | APOHEMOGLOBIN-HAPTOGLOBIN COMPLEXES AND METHODS OF USING THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2022-07-14 | — | — | US | disclosed |
| EP-0544412-A2 | Rhenium and technetium complexes containing a hypoxia-localizing moiety | BRACCO INTERNATIONAL B.V. (NL) | 1993-06-02 | — | — | EP | disclosed |
| EP-0123504-B1 | COMPLEXES OF TECHNETIUM-99M WITH ALKYLENE AMINE OXIMES | AMERSHAM INTERNATIONAL plc (GB) | 1989-09-20 | — | — | EP | disclosed |
| US-4615876-A | IMAGING BY SCINTILLATION SCANNING | CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 1986-10-07 | — | — | US | disclosed |
| EP-0123504-A2 | Complexes of technetium-99m with alkylene amine oximes | AMERSHAM INTERNATIONAL plc (GB) | 1984-10-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140363378-A1 | SELF-ASSEMBLING MOLECULES THAT ACCUMULATE IN ACIDIC TUMOR MICROENVIRONMENTS | TP53, EGFR, HIF1A | KDM4E 4390/4885MAPK1 2547/4885HIF1A 3/4885 |
| US-20220218834-A1 | APOHEMOGLOBIN-HAPTOGLOBIN COMPLEXES AND METHODS OF USING THEREOF | HBG1, HBG2, LPO | KDM4E 4777/4885MAPK1 4496/4885HIF1A 1634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.