Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.72 |
| ▸ | SMO | Q99835 | 4/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551331 | 0.99 | MAPK14 (0.71) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4411010 | 0.93 | MAPK14 (0.73) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4551322 | 0.91 | MAPK14 (0.61) | MAPK14SMOMETHTR2AHTR2C | |
| SCHEMBL4551884 | 0.90 | MAPK14 (0.64) | MAPK14SMOMETHTR2AHTR2C | |
| SCHEMBL4551330 | 0.90 | MAPK14 (0.60) | MAPK14SMOMETHTR2AHTR2C | |
| SCHEMBL4551753 | 0.90 | MAPK14 (0.64) | MAPK14SMOMETHTR2AHTR2C | |
| SCHEMBL5490044 | 0.84 | MAPK14 (0.74) | MAPK14SMO | |
| SCHEMBL14534470 | 0.83 | MAPK14 (0.67) | MAPK14SMOMAPK13MAPK12MAPK11 | |
| SCHEMBL4551883 | 0.83 | MAPK14 (0.55) | MAPK14SMOMETHTR2AHTR2C | |
| SCHEMBL4551752 | 0.82 | MAPK14 (0.54) | MAPK14SMOMETHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |