Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.64 |
| ▸ | SMO | Q99835 | 3/20 | 0.58 |
| ▸ | RHOA | P61586 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2B | P41595 | 3/20 | 0.46 |
| ▸ | RAF1 | P04049 | 4/20 | 0.46 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551884 | 0.99 | MAPK14 (0.64) | MAPK14SMORHOAHTR2AHTR2C | |
| SCHEMBL5490044 | 0.93 | MAPK14 (0.74) | MAPK14SMORAF1BRAFCSF1R | |
| SCHEMBL4551752 | 0.91 | MAPK14 (0.54) | MAPK14SMORHOAHTR2AHTR2C | |
| SCHEMBL4551883 | 0.91 | MAPK14 (0.55) | MAPK14SMORHOAHTR2AHTR2C | |
| SCHEMBL4551331 | 0.90 | MAPK14 (0.71) | MAPK14SMOHTR2AHTR2CHTR2B | |
| SCHEMBL4551323 | 0.90 | MAPK14 (0.72) | MAPK14SMOHTR2AHTR2CHTR2B | |
| SCHEMBL4411010 | 0.83 | MAPK14 (0.73) | MAPK14SMO | |
| SCHEMBL4551330 | 0.83 | MAPK14 (0.60) | MAPK14SMOHTR2AHTR2CHTR2B | |
| SCHEMBL4551322 | 0.82 | MAPK14 (0.61) | MAPK14SMOHTR2AHTR2CHTR2B | |
| SCHEMBL5496963 | 0.79 | MAPK14 (0.44) | MAPK14SMOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |