Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | RAF1 | P04049 | 4/20 | 0.42 |
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5604081 | 0.94 | RAF1 (0.42) | MAPTPOLBKDM4ERAF1BRAF | |
| SCHEMBL4541474 | 0.90 | RAF1 (0.42) | KDM4ERAF1BRAFMAPK14 | |
| SCHEMBL4551777 | 0.90 | BRAF (0.51) | MAPTPOLBKDM4ERAF1BRAF | |
| SCHEMBL4551605 | 0.90 | POLB (0.46) | MAPTPOLBKDM4ESTAT6RAF1 | |
| SCHEMBL5603996 | 0.87 | NAMPT (0.45) | MAPTRAF1BRAFMAPK14MAPK11 | |
| SCHEMBL4551565 | 0.87 | MAPT (0.39) | MAPTKDM4ERAF1BRAFNPC1 | |
| SCHEMBL4551493 | 0.85 | NAMPT (0.43) | MAPTRAF1BRAFMAPK14MAPK11 | |
| SCHEMBL4551975 | 0.85 | L3MBTL1 (0.46) | MAPTPOLBKDM4ENPC1RAB9A | |
| SCHEMBL4551703 | 0.84 | MAPK14 (0.48) | POLBRAF1BRAFMAPK14 | |
| SCHEMBL4552281 | 0.83 | RAF1 (0.45) | RAF1BRAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |