Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.56 |
| ▸ | CBFB | Q13951 | 1/20 | 0.52 |
| ▸ | TERT | O14746 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.48 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | TOP1 | P11387 | 2/20 | 0.48 |
| ▸ | TOP2A | P11388 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551786 | 0.91 | CBFB (0.56) | SIRT2SIRT1CBFBTERTFGFR1 | |
| SCHEMBL4143484 | 0.86 | SIRT2 (0.55) | SIRT2SIRT1CBFBTERTFGFR1 | |
| SCHEMBL4196064 | 0.84 | CBFB (0.62) | SIRT2SIRT1CBFBTERTFGFR1 | |
| SCHEMBL5168732 | 0.80 | CBFB (0.54) | SIRT2SIRT1CBFBFGFR1FLT1 | |
| SCHEMBL4142269 | 0.79 | ALDH1A1 (0.60) | SIRT2SIRT1TERTFGFR1FLT1 | |
| SCHEMBL4139318 | 0.78 | CBFB (0.54) | SIRT2SIRT1CBFBTERTFGFR1 | |
| SCHEMBL14906586 | 0.76 | CBFB (0.66) | SIRT2SIRT1CBFBTERTFGFR1 | |
| SCHEMBL4144680 | 0.76 | CBFB (0.52) | SIRT2SIRT1CBFBFGFR1FLT1 | |
| SCHEMBL15252911 | 0.76 | SIRT2 (0.50) | SIRT2SIRT1CBFBFGFR1FLT1 | |
| SCHEMBL15252879 | 0.76 | SIRT2 (0.50) | SIRT2SIRT1CBFBFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054405-B1 | NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAE WOONG PHARMA (KR) | 2013-09-18 | — | — | EP | disclosed |
| EP-2054405-A1 | NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008007900-A1 | NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2008-01-17 | — | — | WO | disclosed |