SCHEMBL4551798

SCHEMBL4551798

OC(Cl)c1ccc(F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 2/20 0.42
TDO2 P48775 2/20 0.42
AOC3 Q16853 1/20 0.42
HDAC3 O15379 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC1 Q13547 1/20 0.41
HDAC7 Q8WUI4 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC10 Q969S8 1/20 0.41
HDAC11 Q96DB2 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
HDAC6 Q9UBN7 1/20 0.41
HDAC9 Q9UKV0 1/20 0.41
HDAC5 Q9UQL6 1/20 0.41
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 1/20 0.36
LMNA P02545 1/20 0.36
ALPG P10696 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
ORAI1 Q96D31 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL29037476 0.82 PGK1 (0.39)
SCHEMBL424538 0.77 IDO1 (0.46) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL597442 0.77 IDO1 (0.46) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL11603843 0.77 IDO1 (0.46) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL7563025 0.77 IDO1 (0.46) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL6903910 0.77 TSHR (0.50) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL4454516 0.74 IDO1 (0.44) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL14669400 0.74 TSHR (0.55) IDO1TDO2AOC3HDAC4HDAC7
SCHEMBL29021074 0.74 IDO1 (0.44) IDO1TDO2AOC3HDAC3HDAC4
SCHEMBL11780285 0.74 TSHR (0.55) IDO1TDO2AOC3HDAC4HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106608776-B A kind of synthetic method of imines 中国科学院大连化学物理研究所 2019-05-28 CN disclosed
WO-2019060398-A1 THAILANSTATIN ANALOGS PH PHARMA CO., LTD. (KR) 2019-03-28 WO disclosed
CN-109503637-A For treating the noval chemical compound of the disease of helminth 安纳考尔医药公司 2019-03-22 CN disclosed
CN-109153688-A Oxaborolidine esters and uses thereof 安纳考尔医药公司 2019-01-04 CN disclosed
EP-2562164-A1 5-FLUORO PYRIMIDINE DERIVATIVES AS FUNGICIDES Dow AgroSciences LLC (US) 2013-02-27 EP disclosed
WO-2012054315-A1 CATHEPSIN S INHIBITOR COMPOUNDS ELI LILLY AND COMPANY (US) 2012-04-26 WO disclosed