Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 3/20 | 0.44 |
| ▸ | ITGB7 | P26010 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4418816 | 0.91 | ITGB1 (0.54) | L3MBTL1HPGDITGB1ITGA4ITGB7 | |
| SCHEMBL3859687 | 0.90 | CYP2C9 (0.47) | CYP2C9CYP1A2CYP2C19L3MBTL1HPGD | |
| SCHEMBL3859709 | 0.90 | ITGB1 (0.44) | ITGB1ITGA4ITGB7KMT2AMAPK1 | |
| SCHEMBL3855486 | 0.89 | ITGB1 (0.45) | ITGB1ITGA4ITGB7KMT2AMAPK1 | |
| SCHEMBL3858034 | 0.83 | MAPK1 (0.48) | ITGB1ITGA4KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL4422981 | 0.82 | KMT2A (0.40) | ITGB1ITGA4ITGB7KMT2AMAPK1 | |
| SCHEMBL3856996 | 0.81 | P2RX7 (0.48) | L3MBTL1ITGB1ITGA4ITGB7KMT2A | |
| SCHEMBL3851225 | 0.81 | P2RX7 (0.46) | KMT2AMAPK1RAB9AMEN1 | |
| SCHEMBL3859375 | 0.80 | P2RX7 (0.45) | KMT2AMAPK1RAB9AMEN1 | |
| SCHEMBL3850947 | 0.79 | ITGB3 (0.45) | ITGB1ITGA4KMT2AMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592387-A4 | COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS | ELAN PHARM INC (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1592387-A2 | COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS | Elan Pharmaceuticals, Inc. (US) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004066932-A2 | COMPOSITION FOR AND TREATMENT OF DEMYELINATING DISEASES AND PARALYSIS BY ADMINISTRATION OF REMYELINATING AGENTS | ELAN PHARMACEUTICALS INC. (US) | 2004-08-12 | — | — | WO | disclosed |