Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 5/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.36 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.36 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4180445 | 1.00 | NFE2L2 (0.44) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4180439 | 1.00 | NFE2L2 (0.44) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4169581 | 0.89 | NFE2L2 (0.42) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4169585 | 0.89 | NFE2L2 (0.42) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4175534 | 0.89 | GLA (0.42) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4175539 | 0.89 | GLA (0.42) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4170999 | 0.88 | NFE2L2 (0.43) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL4170993 | 0.88 | NFE2L2 (0.43) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL8799920 | 0.88 | NFE2L2 (0.58) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 | |
| Ammonia Solution, Strong SCHEMBL27797122 | 0.85 | NFE2L2 (0.46) | NFE2L2TRPA1CYP1A1CYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | disclosed |