Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4552127 | 0.99 | KCNQ3 (0.51) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4551773 | 0.94 | MAPK14 (0.45) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14534694 | 0.94 | MAPK14 (0.45) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14534471 | 0.92 | MAPK14 (0.50) | KCNQ3KCNQ2MAPK14 | |
| SCHEMBL4552137 | 0.90 | KCNQ3 (0.46) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4551616 | 0.89 | MAPK14 (0.49) | KCNQ3KCNQ2MAPK14 | |
| SCHEMBL4552126 | 0.89 | KCNQ3 (0.46) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4543576 | 0.89 | RAB9A (0.44) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5489512 | 0.89 | CRHR1 (0.49) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4541488 | 0.88 | MAPK14 (0.44) | KCNQ3KCNQ2NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |