Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 6/20 | 0.54 |
| ▸ | MMP9 | P14780 | 6/20 | 0.54 |
| ▸ | MMP8 | P22894 | 6/20 | 0.54 |
| ▸ | MMP13 | P45452 | 6/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 5/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4551984 | 0.86 | TRPV1 (0.50) | SIRT2AMY1ACHEK2TRPV1HDAC6 | |
| SCHEMBL4551530 | 0.86 | AURKA (0.52) | CHEK2HDAC6PTGDR2 | |
| SCHEMBL4151906 | 0.85 | MMP2 (0.52) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL15252345 | 0.84 | MMP2 (0.49) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL4160495 | 0.83 | MMP2 (0.71) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL4149005 | 0.82 | MMP2 (0.69) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL15252712 | 0.82 | MMP2 (0.51) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL15252341 | 0.79 | MMP2 (0.46) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL4140020 | 0.79 | MMP13 (0.52) | MMP2MMP9MMP8MMP13SIRT2 | |
| SCHEMBL4157988 | 0.79 | MMP13 (0.52) | MMP2MMP9MMP8MMP13SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054405-B1 | NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAE WOONG PHARMA (KR) | 2013-09-18 | — | — | EP | disclosed |
| EP-2054405-A1 | NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008007900-A1 | NOVEL BIARYL BENZOIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2008-01-17 | — | — | WO | disclosed |