Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DHODH | Q02127 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL214292 | 0.92 | ATM (0.33) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL213821 | 0.88 | HRH4 (0.42) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL213244 | 0.88 | ALDH1A1 (0.38) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL213924 | 0.88 | ALDH1A1 (0.40) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL213685 | 0.86 | ALDH1A1 (0.38) | GAAMAPTALDH1A1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL213175 | 0.86 | ITGB3 (0.38) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL214630 | 0.86 | HRH3 (0.40) | MAPTALDH1A1KDM4EKMT2ASMN1; SMN2 | |
| SCHEMBL215580 | 0.86 | DRD3 (0.38) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL216099 | 0.85 | MAPT (0.39) | GAAMAPTALDH1A1KDM4EKMT2A | |
| SCHEMBL216125 | 0.84 | ATM (0.41) | MAPTKMT2AHRH4MEN1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2061768-A2 | IMIDAZOLE-4,5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | Exelixis, Inc. (US) | 2009-05-27 | — | — | EP | disclosed |
| WO-2008042282-A2 | IMIDAZOLE-4, 5-DICARBOXAMIDE DERIVATIVES AS JAK-2 MODULATORS | EXELIXIS, INC. (US) | 2008-04-10 | — | — | WO | disclosed |