⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9699093 | 0.83 | — | — | |
| SCHEMBL617496 | 0.79 | — | — | |
| SCHEMBL6684603 | 0.78 | MAOA (0.38) | — | |
| SCHEMBL1028557 | 0.77 | — | — | |
| SCHEMBL12715403 | 0.77 | — | — | |
| SCHEMBL21084369 | 0.77 | MAOA (0.37) | — | |
| SCHEMBL27961020 | 0.77 | MAOA (0.37) | — | |
| SCHEMBL21872484 | 0.74 | MAOA (0.40) | — | |
| SCHEMBL12061582 | 0.74 | MAOA (0.38) | — | |
| SCHEMBL15901770 | 0.74 | MAOA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4771057-A | TREATMENT OF ANGINA, ARRHYTHMIAS, CEREBRALVASCULAR DISEASE AND HYPERTENSION | UNIVERSITY OF ALBERTA (CA) | 1988-09-13 | — | — | US | claimed |
| EP-0239186-A1 | Antihypertensive reduced pyridyl derivatives | The Governors of the University of Alberta (CA) | 1987-09-30 | — | — | EP | claimed |
| US-4514320-A | SALTS OF ALKYLPYRIDINES, NONIONIC SURFACTANT | PETROLITE CORPORATION | 1985-04-30 | — | — | US | claimed |
| US-4446056-A | DISPROPORTIONATION | PETROLITE CORPORATION (US) | 1984-05-01 | — | — | US | claimed |
| EP-2298761-B1 | HIV INHIBITING PYRIMIDINES DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2020-03-25 | — | — | EP | disclosed |
| US-7635775-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2009-12-22 | — | — | US | disclosed |
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| US-7183281-B2 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2007-02-27 | — | — | US | disclosed |
| US-20060293332-A1 | Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. | 2006-12-28 | — | — | US | disclosed |
| US-7074783-B2 | Sulfonylbenzodiazepinone acetamides as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2006-07-11 | — | — | US | disclosed |
| US-7056937-B2 | Sulfonylquinoxalone derivatives as bradykinin antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| US-4771057-A | TREATMENT OF ANGINA, ARRHYTHMIAS, CEREBRALVASCULAR DISEASE AND HYPERTENSION | UNIVERSITY OF ALBERTA (CA) | 1988-09-13 | — | — | US | disclosed |
| EP-0239186-A1 | Antihypertensive reduced pyridyl derivatives | The Governors of the University of Alberta (CA) | 1987-09-30 | — | — | EP | disclosed |
| EP-0239186-A1 | Antihypertensive reduced pyridyl derivatives | The Governors of the University of Alberta (CA) | 1987-09-30 | — | — | EP | disclosed |
| EP-0234776-A2 | Process for 1,4-dihydropyridine compounds | MERCK & CO. INC. (US) | 1987-09-02 | — | — | EP | disclosed |
| US-4446056-A | DISPROPORTIONATION | PETROLITE CORPORATION (US) | 1984-05-01 | — | — | US | disclosed |
| US-4338445-A | N-(Carbonylamino)-tetrahydropyridyl derivatives | CANADIAN PATENTS & DEVELOPMENT LIMITED (CA) | 1982-07-06 | — | — | US | disclosed |
| US-4106904-A | METALS IN AQUEOUS SYSTEMS | PETROLITE CORPORATION (US) | 1978-08-15 | — | — | US | disclosed |
| US-4022785-A | HEXAHYDROTRIAZINES, CORROSION INHIBITOR | PETROLITE CORPORATION (US) | 1977-05-10 | — | — | US | disclosed |