Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29339707 | 0.84 | MEN1 (0.44) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL19716279 | 0.81 | MEN1 (0.47) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL3359322 | 0.80 | KMT2A (0.46) | MEN1NPC1RAB9AKMT2ACMA1 | |
| SCHEMBL29339783 | 0.79 | LTA4H (0.51) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL370507 | 0.79 | KMT2A (0.53) | MEN1NPC1RAB9AKMT2ACMA1 | |
| SCHEMBL3357203 | 0.76 | GSK3B (0.44) | MEN1NPC1RAB9AKMT2ACMA1 | |
| SCHEMBL3356514 | 0.76 | MAPT (0.46) | MEN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL29339883 | 0.75 | AADAT (0.40) | MEN1NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL370625 | 0.75 | MEN1 (0.44) | MEN1NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL31052484 | 0.75 | AADAT (0.49) | MEN1NPC1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124943-A1 | PYRAZOLO [3, 4-B]PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Ranbaxy Laboratories Limited (IN) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008111009-A1 | PYRAZOLO [3, 4-B] PYRIDINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | RANBAXY LABORATORIES LIMITED (IN) | 2008-09-18 | — | — | WO | disclosed |