Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4273456 | 0.90 | HPGD (0.52) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4272521 | 0.87 | HPGD (0.50) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4125534 | 0.85 | HPGD (0.55) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL1853596 | 0.75 | HPGD (0.52) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL1852128 | 0.74 | HPGD (0.55) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL1850906 | 0.73 | HPGD (0.58) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL13699719 | 0.73 | MAPT (0.60) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL7091790 | 0.73 | LMNA (0.58) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4277770 | 0.73 | KMT2A (0.47) | TSHRHPGDALDH1A1KMT2AHSD17B10 | |
| SCHEMBL4280778 | 0.71 | KMT2A (0.45) | TSHRHPGDALDH1A1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |