Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.50 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046627 | 0.90 | OPRM1 (0.45) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL12893174 | 0.89 | ESR1 (0.68) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL2496081 | 0.89 | ESR1 (0.68) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL2640042 | 0.87 | ESR1 (0.46) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL379394 | 0.87 | ESR1 (0.46) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL31490381 | 0.87 | ESR1 (0.46) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL444739 | 0.85 | ESR1 (0.44) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL29415365 | 0.85 | ESR1 (0.44) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| SCHEMBL9838331 | 0.83 | ESR1 (0.43) | ESR1ESR2AKR1C1HDAC4MEN1 | |
| Hydrogen Peroxide SCHEMBL2349581 | 0.83 | ESR1 (0.62) | ESR1ESR2AKR1C1HDAC4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104447792-A | Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof | SANOFI AVENTIS | 2015-03-25 | — | — | CN | disclosed |
| CN-101675060-A | Substituted dihydro and tetrahydro oxazolopyrimidinones, their preparation and use | SANOFI AVENTIS | 2010-03-17 | — | — | CN | disclosed |
| EP-2137193-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | Sanofi-Aventis (FR) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008112483-A2 | SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF | SANOFI-AVENTIS (FR) | 2008-09-18 | — | — | WO | disclosed |