Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 3/20 | 0.39 |
| ▸ | FPR2 | P25090 | 3/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 7/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL63832 | 0.88 | FGFR1 (0.38) | FPR1FPR2FGFR3MAPTFGFR1 | |
| SCHEMBL63798 | 0.77 | CYP19A1 (0.40) | FGFR3FGFR1FGFR2KDRP2RX3 | |
| SCHEMBL63665 | 0.69 | NR3C2 (0.43) | MAPTALDH1A1P2RX3 | |
| SCHEMBL18054715 | 0.69 | CYP19A1 (0.40) | FGFR1FGFR2P2RX3 | |
| SCHEMBL4429135 | 0.64 | CYP19A1 (0.44) | FGFR3FGFR1FGFR2KDRALDH1A1 | |
| SCHEMBL63429 | 0.63 | ALKBH1 (0.37) | MAPTALDH1A1P2RX3 | |
| SCHEMBL63851 | 0.63 | TLR7 (0.39) | MAPTALDH1A1 | |
| SCHEMBL64487 | 0.63 | ADRA1A (0.43) | MAPTALDH1A1 | |
| SCHEMBL1167967 | 0.62 | MAPT (0.50) | MAPTFGFR2KDRALDH1A1 | |
| SCHEMBL63568 | 0.61 | FGFR1 (0.48) | FGFR3MAPTFGFR1FGFR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |