Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3885802 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL1644336 | 0.76 | THRB (0.51) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL1647385 | 0.72 | SMN1; SMN2 (0.79) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL1647405 | 0.72 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL4618649 | 0.71 | THRB (0.50) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL4639921 | 0.71 | SMN1; SMN2 (0.61) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL1644684 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL4638493 | 0.69 | SMN1; SMN2 (0.56) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL1645710 | 0.69 | SMN1; SMN2 (0.70) | SMN1; SMN2L3MBTL1THRBMAPTHTT | |
| SCHEMBL2093494 | 0.68 | NPSR1 (0.48) | SMN1; SMN2L3MBTL1MAPTHTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |