Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 5/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL739312 | 0.98 | GAA (0.47) | TDP1GAAHTTADRA2ALMNA | |
| SCHEMBL29991297 | 0.98 | GAA (0.47) | TDP1GAAHTTADRA2ALMNA | |
| SCHEMBL1249938 | 0.84 | TDP1 (0.42) | TDP1HTTPOLBHSD17B10 | |
| SCHEMBL11609822 | 0.84 | HTT (0.54) | TDP1HTTLMNAPOLBPIK3CB | |
| SCHEMBL28536392 | 0.84 | HRH4 (0.47) | TDP1HTTADRA2A | |
| SCHEMBL21047640 | 0.82 | MKNK1 (0.42) | TDP1GAAHTTPOLBTNF | |
| SCHEMBL10384099 | 0.81 | MKNK1 (0.43) | TDP1GAAHTTADRA2ALMNA | |
| SCHEMBL7196401 | 0.81 | TDP1 (0.58) | TDP1HTTLMNAPOLBTNF | |
| SCHEMBL21047632 | 0.81 | MKNK1 (0.42) | TDP1GAAHTTLMNATSHR | |
| Fluoride SCHEMBL7486853 | 0.80 | HTT (0.54) | TDP1GAAHTTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4264454-A | — | — | None | — | — | JP | disclosed |
| CN-106565644-A | 3- alkyl-5-hydroxy-4-aryl furanone derivative and preparation method thereof | 上海大学 | 2017-04-19 | — | — | CN | disclosed |
| EP-1597229-B1 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | MERCK SERONO SA (CH) | 2009-11-18 | — | — | EP | disclosed |
| US-20070037806-A1 | Such as (3EZ,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime which blocks oxytocin receptors; for prevention and/or treatment of preterm labor, premature birth or dysmenorrhea | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2007-02-15 | — | — | US | disclosed |
| EP-1597229-A2 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004076407-A2 | PYRROLIDINE DERIVATIVES AS OXYTOCIN ANTAGONISTS | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (NL) | 2004-09-10 | — | — | WO | disclosed |
| JP-H04264454-A | IMAGE FORMING METHOD | RICOH CO LTD | 1992-09-21 | — | — | JP | disclosed |
| EP-0013899-A2 | Basic dyestuffs and their use in dyeing paper | BASF Aktiengesellschaft (DE) | 1980-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070037806-A1 | Such as (3EZ,5S)-5-(hydroxymethyl)-1-[(2'-methyl-1,1'-biphenyl-4-yl)carbonyl]pyrrolidin-3-one O-methyloxime which blocks oxytocin receptors; for prevention and/or treatment of preterm labor, premature birth or dysmenorrhea | OXTR, PRLHR, OPRL1 | TDP1 3155/4885GAA 4885/4885HTT 3367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.