Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | AR | P10275 | 6/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338999 | 0.82 | POLB (0.50) | POLBGAAARIMPDH2IMPDH1 | |
| SCHEMBL30934831 | 0.82 | POLB (0.50) | POLBGAAARIMPDH2IMPDH1 | |
| SCHEMBL11208196 | 0.82 | MAPK1 (0.58) | ARALDH1A1MAPK1HTTL3MBTL1 | |
| SCHEMBL8975491 | 0.81 | IMPDH2 (0.50) | POLBGAAARRAF1MAP2K1 | |
| SCHEMBL4085854 | 0.79 | TSHR (0.53) | POLBGAAARMAP2K1MAPT | |
| Anisole SCHEMBL28131523 | 0.79 | POLB (0.71) | POLBGAAARMAPTIMPDH2 | |
| SCHEMBL19820790 | 0.78 | POLB (0.63) | POLBGAAARIMPDH2IMPDH1 | |
| SCHEMBL30441601 | 0.76 | GAA (0.72) | POLBGAAARMAPTALDH1A1 | |
| SCHEMBL1162713 | 0.76 | GAA (0.72) | POLBGAAARMAPTALDH1A1 | |
| SCHEMBL12100932 | 0.76 | HTR1A (0.44) | POLBGAAARMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2129668-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | Janssen Pharmaceutica N.V. (BE) | 2009-12-09 | — | — | EP | disclosed |
| WO-2008109727-A1 | SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-09-12 | — | — | WO | disclosed |