Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.45 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14140577 | 0.80 | NPC1 (0.56) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL4552469 | 0.80 | NPC1 (0.56) | MEN1NPC1RAB9AKMT2A | |
| SCHEMBL25170515 | 0.78 | KCNH2 (0.45) | HDAC3HDAC8 | |
| SCHEMBL4553061 | 0.76 | FFAR1 (0.41) | SRCNR1H4BCL2L11BCL2L1MCL1 | |
| SCHEMBL26454236 | 0.76 | CCNC (0.41) | HDAC6NPC1RAB9A | |
| SCHEMBL22576897 | 0.75 | ALDH1A1 (0.38) | SRCNR1H4BCL2L11BCL2L1MCL1 | |
| SCHEMBL5053636 | 0.73 | CYP19A1 (0.45) | SRCNR1H4HSP90AA1HSP90AB1HDAC3 | |
| SCHEMBL28497312 | 0.72 | MITF (0.39) | SRCBCL2L11BCL2L1MCL1HDAC6 | |
| SCHEMBL22958957 | 0.72 | SRC (0.52) | SRCHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22959003 | 0.71 | SRC (0.58) | SRCHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101610674-A | Sphingosine-1-phosphate ester receptor stimulating agent and agonist compounds | ABBOTT LAB (US) | 2009-12-23 | — | — | CN | disclosed |
| EP-2120575-A1 | SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS | Abbott Laboratories (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008079382-A1 | SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008079382-A1 | SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS | ABBOTT LABORATORIES (US) | 2008-07-03 | — | — | WO | disclosed |