Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | AGXT | P21549 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4433704 | 0.98 | CYP19A1 (0.41) | CYP19A1MEN1KMT2ADHFRIDO1 | |
| SCHEMBL29696195 | 0.73 | CYP19A1 (0.49) | CYP19A1MEN1KMT2ACALM1ALDH1A1 | |
| SCHEMBL4914730 | 0.71 | — | — | |
| SCHEMBL4903292 | 0.68 | — | — | |
| SCHEMBL17713727 | 0.68 | APP (0.46) | IDO1AGXTCALM1ALDH1A1 | |
| SCHEMBL1491056 | 0.66 | MEN1 (0.57) | MEN1KMT2AIDO1AGXTALDH1A1 | |
| SCHEMBL7098582 | 0.65 | ALDH1A1 (0.48) | CYP19A1IDO1AGXTABCB1CALM1 | |
| SCHEMBL1491084 | 0.65 | ALDH1A1 (0.56) | MEN1KMT2AALDH1A1 | |
| SCHEMBL31052 | 0.64 | ALDH1A1 (0.58) | CYP19A1IDO1AGXTABCB1CALM1 | |
| SCHEMBL7889540 | 0.64 | ALDH1A1 (0.58) | CYP19A1IDO1AGXTABCB1EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |