Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555485 | 0.87 | GPR119 (0.39) | GPR119USP30LMNANPSR1 | |
| SCHEMBL4555034 | 0.82 | GPR119 (0.51) | GPR119USP30 | |
| SCHEMBL4553358 | 0.81 | GPR119 (0.41) | GPR119NPC1RAB9A | |
| SCHEMBL4555415 | 0.79 | GPR119 (0.39) | GPR119LMNA | |
| SCHEMBL4554044 | 0.79 | GPR119 (0.50) | GPR119NPC1USP30 | |
| SCHEMBL4554610 | 0.78 | GPR119 (0.38) | GPR119 | |
| SCHEMBL4555039 | 0.74 | GPR119 (0.48) | GPR119JAK2 | |
| SCHEMBL4555036 | 0.73 | GPR119 (0.37) | GPR119USP30 | |
| SCHEMBL4555411 | 0.71 | GPR119 (0.52) | GPR119NPC1 | |
| SCHEMBL31329751 | 0.71 | DDB1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |