Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555415 | 0.86 | GPR119 (0.39) | GPR119ALDH1A1 | |
| SCHEMBL4554610 | 0.85 | GPR119 (0.38) | GPR119ALDH1A1 | |
| SCHEMBL4555034 | 0.85 | GPR119 (0.51) | GPR119USP30 | |
| SCHEMBL28412863 | 0.81 | GPR119 (0.45) | GPR119 | |
| SCHEMBL29757596 | 0.81 | GPR119 (0.45) | GPR119 | |
| SCHEMBL30403961 | 0.80 | GPR119 (0.51) | GPR119NPC1ALDH1A1USP30 | |
| SCHEMBL4555485 | 0.80 | GPR119 (0.39) | GPR119ALDH1A1USP30 | |
| SCHEMBL29989420 | 0.79 | GPR119 (0.50) | GPR119NPC1ALDH1A1 | |
| SCHEMBL4553746 | 0.79 | GPR119 (0.38) | GPR119NPC1USP30 | |
| SCHEMBL4555039 | 0.78 | GPR119 (0.48) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |