Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | PPARG | P37231 | 1/20 | 0.30 |
| ▸ | PPARD | Q03181 | 1/20 | 0.30 |
| ▸ | PPARA | Q07869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553080 | 0.91 | PTGS2 (0.34) | PTGDR2PPARG | |
| SCHEMBL4553942 | 0.80 | ROCK2 (0.33) | MAPK8MAPK9ROCK2PIM1PIM3 | |
| SCHEMBL4555121 | 0.77 | MAPK8 (0.35) | MAPK8MAPK9MAPK10ROCK2PIM1 | |
| SCHEMBL4553079 | 0.77 | NR1I2 (0.35) | PTGDR2 | |
| SCHEMBL4553882 | 0.75 | IRAK4 (0.33) | MAPK8MAPK9MAPK10ROCK2PIM1 | |
| SCHEMBL4553442 | 0.75 | MEN1 (0.41) | ROCK2PIM1PIM3PTGDR2SMN1; SMN2 | |
| SCHEMBL4554738 | 0.75 | MAPK8 (0.33) | MAPK8MAPK9MAPK10ROCK2PIM1 | |
| SCHEMBL4554651 | 0.74 | NPY5R (0.34) | MAPK8MAPK9MAPK10ROCK2PIM1 | |
| SCHEMBL961862 | 0.73 | PTGDR2 (0.48) | MAPK8MAPK9MAPK10PTGDR2 | |
| SCHEMBL4554827 | 0.73 | OXER1 (0.31) | MAPK8MAPK9MAPK10IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |