Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.49 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.46 |
| ▸ | IDO1 | P14902 | 2/20 | 0.46 |
| ▸ | AGXT | P21549 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL64295 | 0.88 | ALKBH1 (0.43) | MAOBMAPTKDM4EALDH1A1MAOA | |
| SCHEMBL4554000 | 0.85 | MAOB (0.43) | MAOBMAPTKDM4EALDH1A1MAOA | |
| SCHEMBL63220 | 0.80 | NR3C2 (0.47) | MAOBMAPTKDM4EALDH1A1MAOA | |
| SCHEMBL63429 | 0.73 | ALKBH1 (0.37) | MAPTKDM4EALDH1A1ALKBH1HTT | |
| SCHEMBL8965939 | 0.70 | MAOB (0.55) | MAOBMAPTIDO1AGXTSMN1; SMN2 | |
| SCHEMBL3117466 | 0.70 | MAOB (0.61) | MAOBMAPTMRGPRX4IDO1AGXT | |
| SCHEMBL13263642 | 0.70 | MAOB (0.79) | MAOBMRGPRX4IDO1AGXTSMN1; SMN2 | |
| SCHEMBL3649253 | 0.69 | MRGPRX4 (0.76) | MAOBMRGPRX4ALKBH1SMN1; SMN2TP53 | |
| SCHEMBL31083932 | 0.69 | MMP1 (0.59) | MAOBMAPTKDM4EALDH1A1MAOA | |
| Hydrochloric Acid SCHEMBL4431437 | 0.69 | MAOB (0.55) | MAOBMAPTIDO1AGXTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |