Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3307205 | 0.86 | NR1H2 (0.49) | L3MBTL1AKR1C3AKR1C2CYP11B1CYP11B2 | |
| SCHEMBL1179665 | 0.76 | CYP11B1 (0.66) | CYP11B1CYP11B2KDM4EMAPK1RXFP1 | |
| SCHEMBL3242200 | 0.75 | L3MBTL1 (0.45) | L3MBTL1AKR1C3AKR1C2KDM4EMAPK1 | |
| SCHEMBL15347894 | 0.74 | AKR1C3 (0.46) | L3MBTL1AKR1C3AKR1C2KDM4EALDH1A1 | |
| SCHEMBL3303538 | 0.71 | PDGFRB (0.48) | L3MBTL1CYP11B1CYP11B2KDM4EALDH1A1 | |
| SCHEMBL6714830 | 0.71 | RXFP1 (0.75) | L3MBTL1CYP11B1CYP11B2KDM4EMAPK1 | |
| SCHEMBL29597984 | 0.70 | RXFP1 (0.56) | L3MBTL1CYP11B1CYP11B2KDM4EMAPK1 | |
| SCHEMBL29651074 | 0.70 | MAPK1 (0.69) | L3MBTL1KDM4EMAPK1ALDH1A1RXFP1 | |
| SCHEMBL29651058 | 0.70 | MAPK1 (0.69) | L3MBTL1KDM4EMAPK1ALDH1A1RXFP1 | |
| SCHEMBL70712 | 0.70 | MAPK1 (0.69) | L3MBTL1KDM4EMAPK1ALDH1A1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121655-A1 | NOVEL 2-HETEROARYL SUBSTITUTED INDOLES 695 | AstraZeneca AB (SE) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008108729-A1 | NOVEL 2-HETEROARYL SUBSTITUTED INDOLES 695 | ASTRAZENECA AB (SE) | 2008-09-12 | — | — | WO | disclosed |