Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3242825 | 0.87 | MAPT (0.42) | L3MBTL1TDP1ALOX5APALDH1A1KDM4E | |
| SCHEMBL3857449 | 0.86 | TDP1 (0.45) | L3MBTL1TDP1ALOX5APALDH1A1KDM4E | |
| SCHEMBL4554042 | 0.75 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1KDM4EMAPK1AKR1C3 | |
| SCHEMBL812065 | 0.71 | KDM4E (0.59) | L3MBTL1TDP1ALDH1A1KDM4EHTT | |
| SCHEMBL15347894 | 0.70 | AKR1C3 (0.46) | L3MBTL1ALDH1A1KDM4EAKR1C3AKR1C2 | |
| SCHEMBL3263775 | 0.68 | KDM4E (0.45) | L3MBTL1TDP1ALOX5APALDH1A1KDM4E | |
| SCHEMBL17422732 | 0.68 | KDM4E (0.54) | L3MBTL1ALDH1A1KDM4EAKR1C3AKR1C2 | |
| SCHEMBL3202603 | 0.68 | HDAC6 (0.47) | L3MBTL1ALDH1A1KDM4EMAPK1AKR1C3 | |
| SCHEMBL7649536 | 0.67 | TDP1 (0.59) | L3MBTL1TDP1ALDH1A1KDM4EMEN1 | |
| SCHEMBL13828206 | 0.67 | SLC6A2 (0.56) | L3MBTL1ALDH1A1KDM4EPLA2G2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102204-B1 | NEW AMINOPYRROLO[1,2- A]INDOLE ET AMINOPYRIDAZINO[1,6-A]INDOLE DERIVATIVES, METHOD FOR PREPARING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | SERVIER LAB (FR) | 2010-05-05 | — | — | EP | disclosed |