Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
| ▸ | PHGDH | O43175 | 7/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.30 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.30 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.30 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.30 |
| ▸ | ADA | P00813 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553763 | 0.94 | ADA (0.31) | NPY5RCRHR1ADA | |
| SCHEMBL4555123 | 0.92 | MAPK8 (0.33) | MAPK8MAPK9MAPK10PHGDHPIM1 | |
| SCHEMBL4554830 | 0.91 | OXER1 (0.31) | PHGDH | |
| SCHEMBL4554440 | 0.89 | KMO (0.31) | MAPK8MAPK9MAPK10NPY5R | |
| SCHEMBL4553884 | 0.87 | IRAK4 (0.33) | PHGDHPIM1ROCK2PIM3NPY5R | |
| SCHEMBL4554653 | 0.86 | NPY5R (0.38) | PHGDHPIM1ROCK2PIM3NPY5R | |
| SCHEMBL4553446 | 0.86 | MEN1 (0.40) | PHGDHPIM1ROCK2PIM3TRPM8 | |
| SCHEMBL4554134 | 0.83 | PHGDH (0.34) | MAPK8MAPK9MAPK10PHGDHPIM1 | |
| SCHEMBL4554738 | 0.82 | MAPK8 (0.33) | MAPK8MAPK9MAPK10PHGDHPIM1 | |
| SCHEMBL4554506 | 0.80 | NPY5R (0.38) | NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |