Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 14/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.30 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966982 | 0.78 | PHGDH (0.34) | PHGDHMEN1KMT2ANPY5R | |
| SCHEMBL965948 | 0.76 | LMNA (0.34) | PHGDHKMT2A | |
| SCHEMBL966800 | 0.76 | USP2 (0.36) | PHGDHKMT2A | |
| SCHEMBL967888 | 0.75 | MAPK8 (0.34) | PHGDHMEN1KMT2AMAPK8MAPK9 | |
| SCHEMBL966868 | 0.72 | SLC6A2 (0.35) | PHGDHMAPK8MAPK9MAPK10 | |
| SCHEMBL967867 | 0.71 | PHGDH (0.35) | PHGDHMEN1KMT2AMAPK8 | |
| SCHEMBL964534 | 0.70 | ALDH1A1 (0.37) | KMT2A | |
| SCHEMBL4555123 | 0.70 | MAPK8 (0.33) | PHGDHMEN1KMT2ANPY5RMAPK8 | |
| SCHEMBL962091 | 0.70 | PHGDH (0.34) | PHGDHMEN1KMT2AMAPK8 | |
| SCHEMBL963807 | 0.70 | MEN1 (0.36) | PHGDHMEN1KMT2AMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2118066-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | Takeda Pharmaceutical Company Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008099794-A1 | FUSED RING COMPOUNDS AS PARTIAL AGONISTS OF PPAR-GAMMA | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-08-21 | — | — | WO | disclosed |