Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3154774 | 0.93 | ALDH1A1 (0.41) | FGFR1ALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL1680787 | 0.85 | CA12 (0.46) | ALDH1A1MAPTLMNAL3MBTL1IMPDH2 | |
| SCHEMBL4554300 | 0.74 | FGFR1 (0.39) | FGFR1ALDH1A1MAPTLMNACA12 | |
| SCHEMBL20661372 | 0.71 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAL3MBTL1CA12 | |
| SCHEMBL27748064 | 0.71 | CYP4F2 (0.43) | ALDH1A1MAPTLMNAL3MBTL1IMPDH2 | |
| SCHEMBL22623624 | 0.70 | CA12 (0.47) | ALDH1A1MAPTLMNAL3MBTL1CA12 | |
| SCHEMBL19878641 | 0.69 | CA12 (0.50) | ALDH1A1LMNAL3MBTL1IMPDH2CA12 | |
| SCHEMBL544803 | 0.69 | PKM (0.47) | ALDH1A1LMNAL3MBTL1CA12CA1 | |
| SCHEMBL19739792 | 0.68 | CA12 (0.42) | ALDH1A1MAPTLMNAL3MBTL1CA12 | |
| SCHEMBL25905328 | 0.67 | CA12 (0.45) | ALDH1A1MAPTLMNAL3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136807-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | Glaxo Group Limited (GB) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008125594-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2008-10-23 | — | — | WO | disclosed |