Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554859 | 0.88 | FFAR1 (0.47) | NPC1RAB9ASMN1; SMN2TRPV1FFAR1 | |
| SCHEMBL4536251 | 0.86 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2TRPV1TP53 | |
| SCHEMBL4515791 | 0.84 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2TRPV1TP53 | |
| SCHEMBL4512876 | 0.84 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2TRPV1TP53 | |
| SCHEMBL4521691 | 0.84 | TRPV1 (0.40) | NPC1RAB9ASMN1; SMN2TRPV1FFAR1 | |
| SCHEMBL4530589 | 0.83 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2TRPV1TP53 | |
| SCHEMBL16927509 | 0.83 | ALDH1A1 (0.41) | NPC1RAB9ASMN1; SMN2TRPV1FFAR1 | |
| SCHEMBL4514053 | 0.83 | TRPV1 (0.62) | NPC1RAB9ASMN1; SMN2TRPV1TP53 | |
| SCHEMBL4529910 | 0.82 | RAB9A (0.53) | NPC1RAB9ASMN1; SMN2FFAR1TP53 | |
| SCHEMBL4530613 | 0.82 | ALDH1A1 (0.44) | NPC1RAB9ASMN1; SMN2TRPV1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124563-A1 | BENZIMIDAZOLE TRPV1 INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008076752-A1 | BENZIMIDAZOLE TRPV1 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-06-26 | — | — | WO | disclosed |