Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.44 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.44 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6369261 | 0.96 | ALDH1A1 (0.57) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL6135228 | 0.90 | ALDH1A1 (0.67) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL6134915 | 0.89 | ALDH1A1 (0.65) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL63892 | 0.88 | ALDH1A1 (0.63) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL64181 | 0.86 | ALDH1A1 (0.49) | ALDH1A1POLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6369256 | 0.86 | ALDH1A1 (0.61) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL64407 | 0.85 | ALDH1A1 (0.58) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL63474 | 0.85 | ALDH1A1 (0.59) | ALDH1A1POLBHPGDHTTSMN1; SMN2 | |
| SCHEMBL64179 | 0.83 | HRH3 (0.50) | ALDH1A1POLBNPC1RAB9AMBTD1 | |
| SCHEMBL6538435 | 0.82 | ALDH1A1 (0.60) | ALDH1A1POLBHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2125748-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | AstraZeneca AB (SE) | 2009-12-02 | — | — | EP | disclosed |
| WO-2008075068-A2 | ACYLAMINOPYRAZOLES AS FGFR INHIBITORS | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |