Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.38 |
| ▸ | ALPL | P05186 | 6/20 | 0.35 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KIT | P10721 | 1/20 | 0.33 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3609534 | 0.84 | MAP4K2 (0.40) | MAP4K2ALPLDPP4EGLN2ALPG | |
| SCHEMBL4553917 | 0.83 | DPP4 (0.34) | ALPLDPP4EGLN2SLC2A1 | |
| SCHEMBL10269994 | 0.82 | IDO1 (0.41) | MAP4K2 | |
| SCHEMBL3603979 | 0.81 | ALPL (0.43) | MAP4K2ALPLDPP4EGLN2ALPG | |
| Trifluoroacetic Acid SCHEMBL3605360 | 0.81 | DPP4 (0.38) | MAP4K2ALPLDPP4EGLN2ALPG | |
| SCHEMBL4555670 | 0.81 | MAP4K2 (0.34) | MAP4K2SYKCDC7PLK4DYRK3 | |
| SCHEMBL3608864 | 0.79 | EGLN2 (0.41) | MAP4K2ALPLDPP4EGLN2ALPG | |
| SCHEMBL10270149 | 0.79 | DPP4 (0.43) | MAP4K2DPP4EGLN2GSK3B | |
| SCHEMBL3613066 | 0.77 | GSK3B (0.40) | MAP4K2ALPLDPP4EGLN2ALPG | |
| Trifluoroacetic Acid SCHEMBL9102535 | 0.76 | DPP4 (0.35) | MAP4K2ALPLDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137188-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Pharma AG (DE) | 2012-06-06 | — | — | EP | disclosed |
| EP-2137188-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008113469-A2 | SUBSTITUTED IMIDAZOPYRIMIDINES AND TRIAZOLOPYRIMIDINES | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-09-25 | — | — | WO | disclosed |