Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1647297 | 0.84 | ALDH1A1 (0.58) | KDM4ESMN1; SMN2NPC1RAB9APPARG | |
| SCHEMBL7984046 | 0.74 | USP2 (0.52) | KDM4ESMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL11877154 | 0.73 | ALDH1A1 (0.59) | KDM4ESMN1; SMN2NPC1RAB9ALTA4H | |
| SCHEMBL1646027 | 0.71 | SMN1; SMN2 (0.57) | KDM4ESMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL4639921 | 0.71 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL1645710 | 0.70 | SMN1; SMN2 (0.70) | KDM4ESMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL1645361 | 0.70 | LMNA (0.61) | SMN1; SMN2NPC1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL1644958 | 0.70 | EPHX2 (0.57) | USP2ALDH1A1KMT2AMAPTLMNA | |
| SCHEMBL11898739 | 0.69 | NPC1 (0.97) | NPC1RAB9ALTA4HHRH3 | |
| SCHEMBL1647385 | 0.69 | SMN1; SMN2 (0.79) | KDM4ESMN1; SMN2NPC1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097413-A1 | 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G Limited (GB) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008062182-A1 | 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS | F2G LTD (GB) | 2008-05-29 | — | — | WO | disclosed |