Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 8/20 | 0.45 |
| ▸ | BCR | P11274 | 8/20 | 0.45 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555145 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2MAPTHCRTR2HCRTR1ALDH1A1 | |
| SCHEMBL3488239 | 0.83 | GPR119 (0.57) | SMN1; SMN2MAPT | |
| SCHEMBL16209160 | 0.78 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL16209159 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL31205619 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL12082607 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL17512451 | 0.75 | MAPT (0.48) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL22836976 | 0.74 | SMN1; SMN2 (0.73) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL17512691 | 0.73 | MAPT (0.48) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 | |
| SCHEMBL25695466 | 0.73 | SMN1; SMN2 (0.71) | SMN1; SMN2MAPTHCRTR2HCRTR1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121661-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | Merck & Co., Inc. (US) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008085316-A1 | BIPIPERIDINYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT | MERCK & CO., INC. (US) | 2008-07-17 | — | — | WO | disclosed |