Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CKS1B | P61024 | 9/20 | 0.42 |
| ▸ | SKP1 | P63208 | 9/20 | 0.42 |
| ▸ | SKP2 | Q13309 | 9/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 2/20 | 0.40 |
| ▸ | BCR | P11274 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4304306 | 0.86 | ABL1 (0.48) | CKS1BSKP1SKP2ABL1BCR | |
| SCHEMBL4307471 | 0.85 | CKS1B (0.41) | CKS1BSKP1SKP2CHRM4GAA | |
| SCHEMBL12082500 | 0.84 | CKS1B (0.54) | SMN1; SMN2MAPTCKS1BSKP1SKP2 | |
| SCHEMBL12082607 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPTABL1BCRHCRTR1 | |
| SCHEMBL4304296 | 0.80 | ROCK2 (0.44) | CKS1BSKP1SKP2 | |
| SCHEMBL27087909 | 0.80 | AURKA (0.42) | MAPTCKS1BSKP1SKP2CHRM4 | |
| SCHEMBL27087916 | 0.80 | AURKA (0.42) | MAPTCKS1BSKP1SKP2CHRM4 | |
| SCHEMBL4554680 | 0.77 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTABL1BCRHCRTR1 | |
| SCHEMBL14812128 | 0.77 | KDM4E (0.44) | MAPTCKS1BSKP1SKP2GAA | |
| SCHEMBL27087915 | 0.77 | USP30 (0.40) | CKS1BSKP1SKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3292110-B1 | N-PIPERIDIN-4-YL DERIVATIVES | MERCK SHARP & DOHME (NL) | 2019-08-21 | — | — | EP | disclosed |
| US-8993757-B2 | N-piperidin-4-yl derivatives | MERCK SHARP & DOHME B.V. (NL) | 2015-03-31 | — | — | US | disclosed |
| US-20140329822-A1 | N-PIPERIDIN-4-YL DERIVATIVES | MERCK SHARP & DOHME B.V. (NL) | 2014-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140329822-A1 | N-PIPERIDIN-4-YL DERIVATIVES | PGR, CYP19A1, BRCA1 | SMN1; SMN2 2841/4885MAPT 4046/4885CKS1B 2254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.